Symbol Name ID |
Dnm1l
dynamin 1-like MGI:1921256 |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Drooling |
Increased CSF lactate |
Abnormality of pattern visual evoked potentials |
Oculomotor apraxia |
Delayed CNS myelination |
Cerebral atrophy |
Athetosis |
Abnormal pyramidal sign |
Restlessness |
Self-biting |
Areflexia |
Encephalopathy |
Epileptic encephalopathy |
Global developmental delay |
Motor delay |
Seizure |
Status epilepticus |
Pain insensitivity |
Disease(s) Associated with DNM1L | |||||||||||||||||||
encephalopathy due to defective mitochondrial and peroxisomal fission 1 | |||||||||||||||||||
optic atrophy 5 |
Mouse Phenotypes | abnormal Purkinje cell mitochondrial morphology |
increased neuron apoptosis |
increased brain apoptosis |
decreased embryonic neuroepithelium thickness |
abnormal brain morphology |
abnormal cerebellum development |
reduced cerebellar foliation |
forebrain hypoplasia |
enlarged brain ventricles |
abnormal brain white matter morphology |
abnormal brainstem morphology |
abnormal cerebellar Purkinje cell layer |
decreased Purkinje cell number |
small cerebellum |
abnormal subarachnoid space morphology |
decreased CNS synapse formation |
abnormal neurite morphology |
abnormal dendritic spine morphology |
abnormal synapse morphology |
abnormal optic disk morphology |
enhanced sensorimotor gating |
increased prepulse inhibition |
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Availability | Mouse Genotype | ||||||||||||||||||||||
Dnm1lem1Hise/Dnm1lem1Hise | |||||||||||||||||||||||
Dnm1lem1Hise/Dnm1lem1Hise Tg(Thy1-EGFP)MJrs/0 |
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Dnm1ltm1.2Miha/Dnm1ltm1.2Miha | |||||||||||||||||||||||
Dnm1ltm1b(KOMP)Wtsi/Dnm1l+ | |||||||||||||||||||||||
Dnm1ltm1.1Hise/Dnm1ltm1.1Hise En1tm2(cre)Wrst/En1+ (conditional) |
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Dnm1ltm1.1Miha/Dnm1ltm1.1Miha Tg(Nes-cre)1Kln/0 (conditional) |
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Dnm1ltm1.1Hise/Dnm1ltm1.2Hise En1tm2(cre)Wrst/En1+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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